Born in Vienna, Kernberg and his family fled Nazi Germany in 1939, emigrating to Chile. He studied biology and medicine and afterwards psychiatry and psychoanalysis with the Chilean Psychoanalytic Society. He first came to the U.S. in 1959 on a Rockefeller Foundation fellowship to study research in psychotherapy with Jerome Frank at the Johns Hopkins Hospital. In 1961 he emigrated to the U.S. joining the C.F. Menninger Memorial Hospital, later became director of the hospital. He was the Supervising and Training Analyst of the Topeka Institute for Psychoanalysis, and Director of the Psychotherapy Research Project of Menninger Foundation. In 1973 he moved to New York where he was Director of the General Clinical Service of the New York State Psychiatry Institute. In 1974 he was appointed Professor of Clinical Psychiatry at the College of Physicians and Surgeons of Columbia University and Training and Supervising Analyst at the Columbia University Center for Psychoanalytic Training and Research. In 1976 he was appointed as Professor of Psychiatry at Cornell University and Director of the Institute for Personality Disorders Institute of the New York Hospital-Cornell Medical Center. He was President of the International Psychoanalytical Association from 1997 to 2001.

His principal contributions have been in the fields of narcissism, object relations theory and personality disorders. He developed a novel and useful framework for coordinating personality disorders along dimensions of structural organization and severity. He was awarded the 1972 Heinz Hartmann Award of the New York Psychoanalytic Society and Institute, the 1975 Edward A. Strecker Award from the Institute of Pennsylvania Hospital, the 1981 George E. Daniels Merit Award of the Association for Psychoanalytic Medicine.

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Derived from Psychotherapy.net, Interview with Otto Kernberg. April.2012